The role of dupilumab in diverse allergic pathologies
DOI:
https://doi.org/10.36105/psrua.2023v2n5.03Palabras clave:
dupilumab, dermatitis atópica, esofagitis eosinofílica, rinosinusitis crónica, asmaResumen
Las respuestas alérgicas representan un importante problema de salud debido a que los tratamientos actuales intentan disminuir la respuesta inmunitaria desencadenada, pero son incapaces de crear una memoria inmunológica que reduzca la intensidad de dicha respuesta. Esto significa que la intensidad de respuesta será igual en cada episodio. Una respuesta alérgica se caracteriza por la liberación exagerada y prolongada de inmunoglobulina E (IgE), lo que desencadena respuestas inmunitarias innatas y la activación de linfocitos T hacia un fenotipo Th2, responsable de la liberación de interleucinas 3 y 4 (IL-3 e IL-4), así como la activación de los linfocitos B hacia células plasmáticas productoras de IgE. Actualmente, los anticuerpos monoclonales (mAbs) se utilizan como tratamiento para diversas patologías alérgicas. Estos mAbs pueden inhibir las vías de señalización de diversas interleucinas, inactivando la diferenciación de linfocitos T y linfocitos B, así como la producción de IgE. Uno de los mAbs más versátiles para el tratamiento de diversas respuestas alérgicas es Dupilumab. Este fármaco está diseñado para inhibir la cadena de señalización de la IL-3 y la IL-4. Específicamente, se une al receptor α de la IL-4 y al complejo de receptores inducidos por las citoquinas IL-13. Dupilumab inhibe las IL-4 e IL-13 a través del receptor 1, deteniendo la liberación de IgE y citoquinas proinflamatorias. Este tratamiento puede utilizarse para controlar la respuesta inflamatoria provocada por los alérgenos. Es importante destacar que el uso de Dupilumab aún no está patentado como tratamiento de elección para las patologías alérgicas. Por este motivo, en esta revisión se recopilan los resultados de los estudios clínicos de Dupilumab y otros mAbs en dermatitis atópica (DA), esofagitis eosinofílica (EoE), rinosinusitis crónica con pólipos nasales (RSC) y asma, con el objetivo de determinar cuál de los mAbs ha proporcionado mejores resultados.
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